What is Avamys® (Fluticasonfuroate)?
Avamys® is a nasal corticosteroid spray with the active ingredient Fluticasonfuroat. It is one of the most effective treatments for allergic rhinitis and is considered as a gold standard for moderate to severe hay fever.
Fluticasonfuroate is a newer corticosteroid with a particularly high binding affinity to the glucocorticoid receptor and a very low systemic absorption. This means: strong local effect in the nose with minimal side effects in the rest of the body.
Avamys® is also characterized by a pleasant spray profile – the fine spray mist is evenly distributed in the nose and causes less irritation than other nasal sprays.
Active Ingredients & Mechanism of Action
Active ingredient: Fluticasonfuroat
Fluticasonfuroate acts as a strong anti-inflammatory corticosteroid in the nasal mucosa:
Active mechanism:
- Ties to the glucocorticoid receptor in the cells of the nasal mucosa
- Inhibits the release of inflammatory mediators (prostaglandins, leukotrienes, cytokines)
- Reduces the immigration of inflammatory cells (eosinophiles, mast cells, lymphocytes)
- Reduces swelling of the nasal mucosa
Activation of symptoms:
- Blocked nose (main advantage over antihistamines)
- Nostrils
- Nope
- Itching
- Also eye symptoms are often improved (naso-ocular reflex)
Initiation of action: A noticeable improvement often occurs after 8 hours. The full effect develops over several days of regular application.
Who is it suitable for?
Avamys® is suitable for:
- Adults and young people from 12 years old with allergic rhinitis
- Children from 6 years (under medical supervision)
- Seasonal and perennial allergic rhinitis
- Moderate to severe symptoms, especially nasal constipation
Especially recommended at:
- Blocked nose as main symptoms (antihistamines are weaker here)
- Inadequate effect of oral antihistamines alone
- Combination with oral antihistamines in severe symptoms
- Long-term treatment of perennial allergies
Not suitable:
- Acute nasal sinus infection (not without medical treatment)
- Nose bleeding or nasal injuries
- After nose surgery (until complete healing)
Available Dosages
Adults and young people aged 12:
- Start dose: 2 spray taps per nostril once a day (= 55 μg × 2 = 110 μg total)
- Maintenance dose for symptom control: 1 spray per nostril once a day (55 μg total)
Children 6-11 years:
- 1 spray per nostril once a day (55 μg total)
- In case of insufficient control: 2 spray taps per nostril (medical control)
Available strength:
- 27.5 μg Fluticasonfuroate per spray jet (120 spray jets per bottle)
Application duration:
- Seasonal: throughout the pollen season
- Ideally start 1–2 weeks before pollen start
- Perennial: All year possible under medical control
How to Take
Application:
- Nose gently sneaking before use
- Shake a bottle
- Insert spray opening into the nose hole, slightly inclined to the outside
- Gently breathe through the nose during spraying
- Do not spray the nose
Important notes:
- Apply once a day, always at the same time
- Regular application is crucial - not only if necessary
- Pre-application: Spray head 6 times pump (priming)
- After 30 days Non-use: Renewed primen
- Clean spray head regularly
Quality:
- Do not put the head in the neck
- Spray easily directed away from the nasal wall
- Don't sneak at the same time - gently breathing
Contraindications
**Avamys® must not be used at:* *
- hypersensitivity to Fluticasonfuroate or any of the other components
Preview at:
- Heavy liver failure (increased systemic exposure)
- Simultaneous treatment with Ritonavir or other strong CYP3A4 inhibitors (increased cortisol suppression)
- Active or latent tuberculosis
- Untreated fungal infection of the nose
- Recent nose surgery or nose injury
- children (long-term use under medical control due to growth)
pregnant and breastfeeding: Should only be applied after strict use-risk weighing. Systemic admission is minimal, yet medical consultation is recommended.
Possible Side Effects
Family (1–10 %):
- Nose bleeding (Epistaxis) – most common side effect
- ulcer of the nasal mucosa
** Occasionally (0.1-1 %):* *
- Headaches
- Nose pain or discomfort
- Nasent dryness
Selten:
- hypersensitivity reactions (Urtikaria, Angioedema)
- Anaphylaxis (extremely rare)
- Nose septumperforation (for long-term use, very rare)
Systemic side effects: Systemic cortisone effects (weight increase, osteoporosis) are not to be expected when used as intended, since the systemic bioavailability of Fluticasonfuroat nasal is less than 0.5%.
** Nose bleeding occurs more frequently when the spray is sprayed directly onto the nostril wall. Proper application technology significantly reduces this risk.
Interactions
Preview with simultaneous use of:
- Ritonavir and other strong CYP3A4 inhibitors (increasing systemic floodicason exposure, cushing risk)
- Ketoconazole, Itraconazole (similar mechanism)
- Other nasal or inhalative corticosteroids (additive cortisol suppression)
No relevant interaction with:
- Oral antihistamines (safe and recommended combination)
- leukotriene antagonists
- Swelling nasal sprays (short time)
** The combination of Avamys® with an oral antihistaminic agent (e.g. Desloratadin) is standard therapy for moderate to severe symptoms.
Frequently Asked Questions
Similar Medications
Is Avamys® (Fluticasonfuroate) right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor. Read the package leaflet before use.