MomeGalen® / Nasonex® (Mometason nasal)

Active mechanism:

• Binding to intracellular glucocorticoid receptors
• inhibits the formation of inflammatory mediators (prostaglandins, leukotrienes)
• Reduces infiltration of eosinophiles, basophiles and mast cells
• Suppresses the allergic inflammatory reaction in the nasal mucosa
• Works swelling on the mucous membrane

Activation of nasal polyps:

• Reduces the size of nose polyps
• Improves nasal breathing
• Can delay an operation or make unnecessary

Initiation of action:

• First improvement frequently after 12 hours
• Clinically relevant effect after 1–2 days
• Full effect after 1–2 weeks of regular application

• Adults and young people from 12 years old with allergic rhinitis
• Children from 3 years (seasonal and perennial rhinitis, according to medical prescription)
• Adults aged 18 with nose polyps
• Seasonal and year-round allergies

Especially recommended at:

• Blocked nose as main symptoms
• Nose polyps with obstruction of nasal nude
• Long-term therapy (best safety profile among nasal corticosteroids)
• Children (aged from 3 years onwards – more experience than with Fluticasonfuroat)

Not suitable:

• Untreated nasal infections (arrows, bacteria)
• Nose bleeding or fresh nasal injuries
• Tuberculosis of the respiratory tract

**Allergic rhinitis – adults and adolescents from 12 years:* *

• 2 spray taps per nostril once a day (= 200 μg total dose)
• Maintenance dose: 1 spray per nostril once a day (= 100 μg)

Allergic rhinitis – children 3–11 years:

• 1 spray per nostril once a day (= 100 μg)

Other polyps – Adults aged 18 and over

• 2 spray taps per nostril twice a day (= 400 μg)
• After improvement: 2 spray taps per nostril once a day

Available strength:

• 50 μg Mometasonfuroate per spray jet (140 spray rams per bottle)

Prophylactic:

• 2–4 weeks before expected pollen start

Application:

• Nose gently
• Shake bottle
• Remove protective cap
• Insert spray opening into the nose hole (directed away from the vaginal wall)
• Once pumping, gently breathing through the nose
• Breathe through the mouth

Important notes:

• Pre-application: 10 times pump (to even spray mist)
• At > 14 days Non-use: 2 times pump
• Regular application for optimal effect
• Clean spray head weekly with warm water
• Do not spray towards the nose wall

Tips:

• left hand for right nostril, right hand for left nostril
• Head slightly forward
• For nasal polyps: Use consequently, even if improvement occurs

**Mometason nasal must not be used at:* *

• hypersensitivity to Mometasonfuroate or other components
• Untreated local infection of the nasal mucosa

Preview at:

• Active or latent tuberculosis
• Herpes simplex of eyes
• Systemic fungal infections
• Medical nose surgery or nose injury
• Long-term application in children (growth control)
• Simultaneous use of other corticosteroids (inhalative, dermal)
• Glaucoma or cataract in history

Family (1–10 %):

• Nose bleeding (Epistaxis)
• Pharyngitis
• Headaches

** Occasionally (0.1-1 %):* *

• Burning or irritation in the nose
• Sneezing after application
• Flavour or odor disorders

Selten:

• Nose septumperforation (for long-term use, very rare)
• hypersensitivity reactions (angioedema, bronchospasm)
• Increased intraocular pressure, glaucoma, cataract (for long-term use)

Preview at:

• Ritonavir and strong CYP3A4 inhibitors (can theoretically increase systemic mometason exposure)
• Other corticosteroids (inhalative, oral, dermal – additive cortisolsuppression)

No relevant interaction with:

• Oral antihistamines (safe combination)
• Loratadin (examined in studies – no interaction)
• leukotriene antagonists (Montelukast)
• Swelling nasal sprays (short term)